在一般人群中血calprotectin和新发型2型糖尿病:一个前性队列研究
Arno R Bourgonje1,2, Martin F Bourgonje3, Sara Sokooti4
1Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, the Netherlands.
The Journal of clinical endocrinology and metabolism
|March 4, 2024
概括
炎症生物标志物calprotectin的升高与患2型糖尿病 (T2D) 的风险增加有关. 这种关联似乎受到超脂血症和整体系统性炎症的影响,而不是直接影响.
科学领域:
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
- 流行病学 流行病学
背景情况:
- 系统性炎症是2型糖尿病 (T2D) 发展的关键因素.
- 骨髓细胞衍生的炎症标志物calprotectin正在研究其在T2D中的作用.
- 了解炎症的作用可以为T2D预防策略提供信息.
研究的目的:
- 调查循环中calprotectin水平与一般人群中新发型T2D风险之间的关联.
- 为了确定calprotectin是否是T2D发展的独立预测因素.
- 探索calprotectin-T2D协会中的潜在效果修饰剂.
主要方法:
- 基于人口的前性队列研究 (PREVEND) 与4815名最初非糖尿病参与者.
- 测量了基线血calprotectin水平.
- 新发病的T2D是由葡萄糖水平,诊断或药物使用来定义的.
主要成果:
- 较高的血calprotectin水平与新发型T2D的风险增加显著相关 (HR每倍 1.42).
- 在调整年龄和性别后,这种关联仍然显著,但在进一步调整高脂血症和hs-CRP后,这种关联减弱了.
- 对于高血压,心血管疾病史,HOMA-IR和降脂药物的使用,观察到效果修饰.
结论:
- 在一般人群中,血calprotectin的升高与患T2D的风险更高有关.
- 蛋白可以作为T2D风险的可修改炎症生物标志物.
- 这种关联可能取决于高脂血症和全身炎症,这表明间接关系.
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