孕期甲状腺激素和与自闭症相关的特征在EARLI和HOME研究中的研究
Caichen Zhong1, Juliette Rando2, Marisa A Patti2
1Department of Epidemiology and Biostatistics, Drexel University, Philadelphia, Pennsylvania, USA.
概括
孕期甲状腺激素,包括甲状腺刺激激素 (TSH) 和自由甲状腺素 (FT4),可能会影响自闭症谱系障碍 (ASD) 相关的特征. 较高的FT4和较低的TSH水平与一般人群研究中的ASD特征增加有关.
科学领域:
- 神经发育障碍 神经发育障碍
- 内分泌学 在内分泌学.
- 产前健康 产前健康
背景情况:
- 甲状腺激素对于胎儿大脑发育至关重要.
- 自闭症谱系障碍 (ASD) 是一种复杂的神经发育状况.
- 关于 ASD 定量特征与怀孕期间特定甲状腺激素水平之间的关联的研究有限.
研究的目的:
- 调查母亲妊娠时甲状腺刺激激素 (TSH) 和自由甲状腺素 (FT4) 水平与自闭症谱系障碍 (ASD) 相关特征之间的关联.
- 检查这些关联与ASD特征的分布和ASD家族风险有关.
主要方法:
- 对两个怀孕队伍的前性分析:早期自闭症风险纵向调查 (EARLI) 和健康结果和环境测量 (HOME) 研究.
- 测量怀孕中期母亲血清中的TSH和FT4水平.
- 在3-8岁儿童中使用社会响应度量 (SRS) 评估与自闭症相关的特征.
- 经过对母体和社会人口统计因素进行调整的量子回归分析.
主要成果:
- 聚合分析显示,较高的母体FT4水平与增加的SRS得分有关,特别是在第95百分点.
- 在综合分析中,较高的母体TSH水平与降低的SRS得分有关.
- 在HOME队列中,TSH和SRS得分之间的关联仍然显著,但在EARLI队列中,最高的SRS百分比没有显著.
结论:
- 孕期甲状腺激素水平,特别是FT4和TSH,与自闭症谱系障碍相关的特征有关.
- 这些关系可能在ASD特征的范围和ASD的家族概率上有所不同.
- 研究结果表明,母体甲状腺功能可能在与ASD相关的神经发育结果中发挥作用.
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