在实验室之间共享参考间隔和监测患者 - - 来自可能可切换的外部质量保证计划的发现
Christopher J L Farrell1, Graham R D Jones2,3, Kenneth A Sikaris4,5
1New South Wales Health Pathology, Liverpool Hospital, Liverpool, Australia.
Clinical chemistry and laboratory medicine
|March 4, 2024
概括
外部质量保证 (EQA) 数据可以评估实验室分析性能是否支持共同参考区间 (CRI) 和临床决策限制. 许多分析品未能达到规格,突出了改善EQA监测系统的需要.
科学领域:
- 临床化学 临床化学
- 实验室医学 实验室医学
- 质量保证 质量保证 质量保证
背景情况:
- 实验室结果越来越多地使用共同参考间隔 (CRI),临床决策极限和纵向患者数据来解释.
- 目前的系统缺乏确定的方法来验证分析性能是否证明了这些解释的合理性.
- 外部质量保证 (EQA) 计划为评估分析性能提供了潜在的数据.
研究的目的:
- 分析EQA数据,以确定当前的分析性能是否证明了共同参考区间 (CRI) 和临床决策界限的解释.
- 评估EQA数据是否适合在不同实验室监测患者测试.
主要方法:
- 评估的仪器组中位数与CRI的最小偏差规范相比.
- 通过使用专业机构规范评估临床决策极限.
- 将全实验室不准确性与患者监测的实体内生物变异进行比较.
主要成果:
- 在所有仪器组中,与澳大利亚CRIs的18种分析品中,有5种未能满足所有仪器组的规格.
- 三糖符合临床决策极限的偏差和不精确性规范;维生素D符合不精确性.
- 只有33%的分析物方法组符合实验室间患者监测的最低不精确性规范.
结论:
- 可切换的EQA程序数据可以有效地监控分析性能是否支持当代实验室解释.
- 电子质量认证提供商应实施系统,以定期与实验室共享这些性能数据.
- 这种监测对于确保实验室结果解释的可靠性至关重要.
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