怀孕期间阻塞性睡眠呼吸暂停的症状与儿童自闭症谱系障碍有关:一项案例对照研究
Julia Nick1,2, Kristin Seaborg3, Kathleen Kastner4
1Department of Obstetrics and Gynecology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
概括
患有阻塞性睡眠呼吸暂停症状的孕妇可能会生孩子,患自闭症谱系障碍的风险更高. 需要进一步的研究来证实这种联系,并探索睡眠呼吸暂停.
科学领域:
- 神经发育障碍 神经发育障碍
- 睡眠的药物 睡眠的药物
- 产科 产科 产科 产科 产科
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 影响了很大一部分怀孕 (10-32%+),对长期儿童健康结果的数据有限.
- 妊娠期间阻塞性睡眠呼吸暂停对儿童神经发育的长期影响尚未得到充分证实.
研究的目的:
- 调查假设,孕期母亲阻塞性睡眠呼吸暂停症状会增加儿童自闭症谱系障碍 (ASD) 的发生率.
- 探索孕妇怀孕期间与睡眠有关的担忧与后代ASD发展之间的联系.
主要方法:
- 采用了一种病例控制研究设计.
- 对比父母的怀孕,他们的孩子被诊断出ASD (有和没有已知的遗传条件).
主要成果:
- 这项研究包括51名父母,4名父母的孩子患有遗传关联的ASD,47名父母的孩子患有非遗传的ASD.
- 怀孕期间打和白天疲劳的发生率在两组之间是相似的.
- 与一般孕妇人口相比,在研究人口中报告的打和驾驶时入睡的更高患病率.
结论:
- 初步发现表明,自闭症儿童的父母中睡眠相关问题的患病率很高.
- 由于与神经发育结果的潜在联系,需要对怀孕期间阻塞性睡眠呼吸暂停 (OSA) 进行进一步的研究.
- 未来的研究应该专注于在怀孕期间出生于有或没有OSA的母亲的孩子的神经发育结果.
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