在急性和慢性心血管疾病患者中降低循环CTRP3水平
Andreas Schmid1, Sabine Pankuweit2, Ann-Kathrin Vlacil2
1Department of Internal Medicine III, Giessen University Hospital, Giessen, Germany. andreas.schmid@innere.med.uni-giessen.de.
Journal of molecular medicine (Berlin, Germany)
|March 4, 2024
概括
在患有慢性或急性冠状动脉疾病 (CAD) 的男性患者中,循环中的CTRP3水平下降. 血CTRP3显示出作为识别男性CAD患者的生物标志物的潜力,但无法区分急性和慢性疾病.
科学领域:
- 心血管医学 心血管医学
- 内分泌学 在内分泌学.
- 生物标志物发现发现
背景情况:
- 与C1q/TNF相关的蛋白3 (CTRP3) 是一种具有代谢和免疫功能的阿迪波金.
- 以前关于CTRP3作为心血管疾病 (CVD) 生物标志物的研究是矛盾的.
- 在冠状动脉疾病 (CAD) 中CTRP3的作用需要进一步研究.
研究的目的:
- 调查慢性冠状动脉综合征 (CCS) 和急性冠状动脉综合征 (ACS) 患者的CTRP3水平.
- 评估CTRP3作为区分CAD严重程度和敏度的潜在生物标志物.
- 将人类患者的CTRP3调节与心血管病理生理学的小鼠模型进行比较.
主要方法:
- 招募了206名患有CCS,ACS (第一次或复发事件) 和49名健康对照患者.
- 通过ELISA测量周围血液中的CTRP3水平.
- 接收器操作特征 (ROC) 曲线分析,以评估男性患者的预测值.
主要成果:
- 与对照组相比,男性CCS和ACS患者的CTRP3水平显著下降 (p < 0.001).
- 在CCS,ACS-1和ACS-2患者组之间没有观察到CTRP3水平的显著差异.
- 血CTRP3证明了用于识别男性CAD患者的预测价值 (切断值51.25 ng/mL),在子组中具有一致的灵敏度和特异性.
- 女性患者的CTRP3水平通常高于男性.
- 与人类男性发现相比,小鼠模型显示部分相反的CTRP3调节.
结论:
- 在患有慢性和急性冠状动脉疾病的男性患者中,循环中的CTRP3水平降低.
- 血CTRP3作为一种潜在的生物标志物,用于识别男性CAD患者.
- CTRP3无法区分急性和慢性冠状动脉疾病的情况.
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