爱斯坦-巴尔病毒在重症监护病人的重新激活:一项前性观察性研究
François Guiouillier1, Jean Derely1, Alexandre Salvadori2
1Service d'Anesthésie-Réanimation, Hôpital d'Instruction des Armées Percy, Clamart, France.
Intensive care medicine
|March 4, 2024
概括
爱斯坦-巴尔病毒 (EBV) 在重症监护室的重新激活与更高的90天死亡率无关,但患者患病率显著增加. 这突出了EBV的EBV.
科学领域:
- 传染性疾病 传染性疾病
- 病毒学 病毒学
- 关键护理医学 关键护理医学
背景情况:
- 众所周知,疹病毒的重新激活,特别是细胞巨乳病毒 (CMV),会增加重症监护室 (ICU) 患者的发病率和死亡率.
- 爱斯坦-巴尔病毒 (EBV),尽管高血清发病率 (>95%),仍然在ICU设置不足研究.
- 预先的数据表明,EBV重新激活与重症患者的不良结果之间存在联系.
研究的目的:
- 为了调查埃普斯坦-巴尔病毒 (EBV) 反激活和入住重症监护室 (ICU) 的患者的发病率和死亡率之间的关联.
主要方法:
- 一项多中心前性研究,涉及129名入院于ICU的患者.
- 聚合酶连锁反应 (PCR) 用于量化EBV病毒载量在入院时和每周两次在ICU停留期间.
- 患者的随访延长到ICU入院后的90天.
主要成果:
- 在129名患者中,70人 (54.3%) 发生了EBV复激活.
- 在EBV再激活和不激活的患者之间,90天死亡率没有显著差异 (25.7%与15.3%,p=0.22).
- EBV再激活与增加的发病率显著相关,包括更少的无呼吸器日,更高的急性呼吸困难综合征 (ARDS) 发病率,感染,败血症休克,以及需要置换疗法. 在入院时重新激活的患者的死亡率高于后来重新激活的患者.
结论:
- 在ICU中的EBV重新激活与90天死亡率的增加无关.
- 埃博病毒的再激活与患者发病率的增加和重症患者更具炎症性免疫特征有显著联系.
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