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发生率和并发症的预测因子在克拉姆阴性血流感染
Utpal Mondal1,2, Erin Warren3, P Brandon Bookstaver3,4
1Department of Medicine, Division of Infectious Diseases, Audie L. Murphy VA Medical Center, San Antonio, TX, USA.
Infection
|March 4, 2024
概括
来自格拉姆阴性血流感染 (GN-BSI) 的并发症影响13.9%的患者,通常在5天内. 风险因素包括内置设备,药物使用和特定细菌,有助于预测不良结果.
科学领域:
- 传染性疾病 传染性疾病
- 临床微生物学 临床微生物学
- 流行病学 流行病学
背景情况:
- 转移性并发症的格拉姆阴性血流感染 (GN-BSI) 发病率还没有得到很好的定义.
- 这项研究调查了90天内GN-BSI并发症的发生和预测因素.
研究的目的:
- 为了确定发生的转移性并发症的发生率后,格拉姆阴性血流感染 (GN-BSI).
- 确定与这些并发症的发展相关的风险因素.
主要方法:
- 从2012年1月到2015年6月,对752名GN-BSI患者进行了回顾性队列研究.
- 卡普兰-梅尔对发病率的分析和风险因素的Cox比例危险回归.
- 确定的并发症包括内心炎,败血性关节炎,骨髓炎,脊髓感染,深层,以及复发性GN-BSI.
主要成果:
- 13.9%的患者在GN-BSI治疗90天内出现并发症,中位数识别时间为5.2天.
- 确定了独立的风险因素:内置的假肢材料,注射药物使用,非尿源,特定的阴性细菌 (S. marcescens,P. mirabilis,P. aeruginosa),早期临床失败和持久的GN-BSI.
- 大肠杆菌是最常见的病原体 (49.9%),尿道是最常见的来源 (50.3%).
结论:
- 经过格兰氏阴性血流感染后的并发症相对较为常见.
- 并发症的预测因素包括初始临床反应,随访血液培养,宿主因素和微生物特征.
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