GH与PRL共分泌和GH分泌的垂体腺瘤之间的差异:一系列604例病例
Marta Araujo-Castro1, Betina Biagetti2, Edelmiro Menéndez Torre3
1Endocrinology & Nutrition Department, Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain.
The Journal of clinical endocrinology and metabolism
|March 4, 2024
概括
增长激素和前素共同分泌的垂体腺瘤 (GH&PRL-PAs) 比GH-PAs更具攻击性和侵入性,导致更频繁的垂体下垂体. 然而,这些瘤类型之间的手术结果和巨的治愈率是相似的.
科学领域:
- 内分泌学 在内分泌学.
- 神经外科 神经外科
- 在瘤学瘤学.
背景情况:
- 关于垂体腺瘤共同分泌生长激素和益生菌素 (GH&PRL-PAs) 的临床过程和结果的数据有限.
- 一些研究表明,与GH分泌垂体腺瘤 (GH-PAs) 相比,GH&PRL-PAs表现出更具侵略性的临床放射性行为.
研究的目的:
- 评估GH-PAs和GH&PRL-PAs之间的临床表现和手术结果的差异.
- 为了比较这两种类型的垂体腺瘤之间的攻击性和对垂体功能的影响.
主要方法:
- 一项多中心的回顾性研究,对604名经过垂体外科手术的壮病患者进行了多中心的回顾性研究.
- 根据血清PRL水平和免疫组织化学,患者被分为GH&PRL-PAs (n=130) 或GH-PAs (n=474) .
主要成果:
- 占病例21.5%的GH&PRL-PAs被诊断在较年轻的年龄,比GH-PAs更大 (90.6%),更具侵入性 (33.6%).
- GH&PRL-PAs更频繁地呈现了手术前的下垂体 (OR 2.8) 和较低的IGF-ULN水平.
- 术后壮症治愈率相似,但GH&PRL-PA患者的永久性阿尔金因-血管压素缺乏症 (AVP-D) 发生率更高 (7.3%与2.4%相比).
结论:
- GH&PRL-PAs约占巨病例的20%,并且表现出更具侵略性的特征,包括更大的尺寸,增加的侵入性和更高的hypopituitarism率.
- 尽管壮症的生物化学治愈率相似,但GH&PRL-PAs与患有永久性术后氨酸-血管压素缺乏症 (AVP-D) 的风险更大.
相关概念视频
Hormones of the Pituitary Gland
6.6K
The small, pea-sized pituitary gland is located at the base of the brain. It is crucial in regulating various bodily functions, from growth to reproduction. The gland is divided into the anterior lobe and the posterior lobe. The secretory cell clusters in the pars distalis of the anterior pituitary lobe are controlled by hypothalamic regulators and synthesize six primary hormones.
The most abundantly secreted hormone from the anterior lobe is the growth hormone, which controls overall growth by...
The most abundantly secreted hormone from the anterior lobe is the growth hormone, which controls overall growth by...
6.6K
Major Hormones and Their Functions
392
Hormones, the biochemical messengers produced by endocrine glands, are pivotal in regulating bodily functions and maintaining homeostasis. Each hormone's balance is crucial; imbalances can lead to significant physiological disruptions. Major hormones include oxytocin, cortisol, epinephrine, estrogen, testosterone, thyroxine, growth hormone, insulin, and glucagon.
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
392
Small GTPases - Ras and Rho
3.9K
Ras and Rho are small monomeric GTPases that act downstream of receptor tyrosine kinase (RTK) and regulate various cellular processes. These GTPases switch between active and inactive states by binding to guanine nucleotides.
Three regulatory proteins control their activity:
Three regulatory proteins control their activity:
3.9K
The Parathyroid Glands
2.1K
The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
2.1K
GPCRs Regulate Adenylyl Cylase Activity
5.5K
Some GPCRs transmit signals through adenylyl cyclase (AC), a transmembrane enzyme. AC helps synthesize second messenger cyclic adenosine monophosphate (cAMP). AC catalyzes cyclization reaction and converts ATP to cAMP by releasing a pyrophosphate. The pyrophosphate is further hydrolyzed to phosphate by the enzyme pyrophosphatase, which drives cAMP synthesis to completion. However, cAMP is rapidly degraded to 5′ AMP by the enzymes phosphodiesterase (PDE), preventing overstimulation of...
5.5K
GTPases and their Regulation
8.4K
Guanine nucleotide-binding proteins (G-proteins), also known as GTPases, are a superfamily of proteins that regulate many cellular processes, such as cell signaling, vesicular transport, and the regulation of cell shape and motility. Mutation or dysfunction of these proteins can lead to disease. There are around 40,000 known G-proteins that can broadly be classified into two groups ‒ small G-proteins consisting of a single domain and large multi-domain G-proteins.
Large G-proteins,...
Large G-proteins,...
8.4K


