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从伊拉克返回的中国移民工人皮肤莱什曼病的临床和实验室特征
Kuo Bi1, Xiaoli Li2,3, Rui Zhang4
1Department of Pathology, Beijing Friendship Hospital, Capital Medical University, Beijing, PR China.
PLoS neglected tropical diseases
|March 4, 2024
概括
从伊拉克返回的中国工人的进口皮肤雷什曼病 (CL) 具有肢体皮肤病变的特征. 通过PCR和植物遗传学分析识别Leishmania major有助于诊断和治疗.
科学领域:
- 医学寄生虫学 医学寄生虫学
- 传染性疾病 传染性疾病
- 旅行 医学 旅行 医学
背景情况:
- 进口皮肤雷什曼病 (CL) 是由于国际旅行而造成的全球健康问题日益增加.
- 非流行地区的医生经常误诊CL,导致治疗延迟和不良结果.
- 本研究的重点是从伊拉克返回的中国工人进口的CL病例.
研究的目的:
- 在中国旅行者中描述从伊拉克进口的Leishmania感染.
- 为管理CL的中国医生提供诊断和治疗见解.
- 为了确定该种群中负责CL的Leishmania物种.
主要方法:
- 诊断包括显微镜检查,寄生虫培养和PCR放大Leishmania特有的内部转录间隔器1 (ITS-1) 基因.
- 对ITS-1序列的遗传学分析用于物种识别和确定地理来源.
- 免疫病理学检查和细胞因子分析 (IFN-γ,IL-6,IL-8) 评估了宿主免疫反应.
主要成果:
- 在从伊拉克返回的中国工人中发现了25例CL病例,其中Leishmania major是主要的物种.
- 临床表现包括沙咬伤史和病变主要发生在暴露的四肢上,性湿病变的患病率更高.
- PCR和ITS-1测序证实了Leishmania感染,并确定了与伊拉克特有菌株密切相关的菌株. 免疫病理学表明Th1偏差的细胞免疫反应.
结论:
- 这些进口CL病例的临床和寄生虫学特征为中国的诊断和治疗提供了有价值的信息.
- 这项研究强调了在从伊拉克等流行地区返回的旅行者中考虑CL的重要性.
- 在治疗皮肤病变方面,抗体内伤注被证明是有效的.
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