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Updated: Jul 1, 2025

Using Lipid Nanoparticles for the Delivery of Chemically Modified mRNA into Mammalian Cells
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基于蒂奥芬的脂质用于将mRNA输送到肺和视网膜组织

Yulia Eygeris1,2, Mohit Gupta1, Jeonghwan Kim1,3

  • 1Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Portland, OR 97201.

Proceedings of the National Academy of Sciences of the United States of America
|March 4, 2024
PubMed
概括

含有硫的新型电离性脂质 (Thio-lipids) 能够有效地传递mRNA. 脂质20b在非人类灵长类动物中显示出强大的视网膜转染,提供了一种新的治疗途径.

关键词:
可离子化脂质的离子化脂质脂质纳米颗粒是一种纳米粒子.提供mRNA的交付.

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In eukaryotes, transcription and translation are compartmentalized; an mRNA is first synthesized in the nucleus and then selectively transported to the cytoplasm for protein synthesis. Before transport, a pre-mRNA undergoes several steps of post-transcriptional modifications including splicing, 5' capping, and the addition of a poly-adenine tail. Various proteins bind to the pre-mRNA during these modifications. The mRNA transport takes place with the help of multiple proteins playing...
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