COVID-19的长期自身免疫性炎症性风湿性结果:一个双国队列研究
Min Seo Kim1, Hayeon Lee2, Seung Won Lee3
1Medical and Population Genetics and Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, Massachusetts (M.S.K.).
Annals of internal medicine
|March 4, 2024
概括
COVID-19诊断增加了自身免疫性炎症性类风湿性疾病 (AIRD) 的长期风险. 与流感或没有感染相比,更严重的COVID-19感染时,这种风险更高.
科学领域:
- 类风湿病学 类风湿病学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 以前的研究表明COVID-19和自身免疫性炎症性类风湿性疾病 (AIRD) 之间存在联系,但存在方法上的限制.
- COVID-19对AIRD发病率的长期影响需要进一步调查.
研究的目的:
- 评估COVID-19感染后发生事件AIRDs的长期风险.
- 为了将这种风险与未感染的个人和流感患者进行比较.
主要方法:
- 使用来自韩国和日本的全国性索赔数据进行了一项双国,纵向,倾向匹配的队列研究.
- 分析了超过1000万名20岁以上的韩国和120万名日本患者,比较了COVID-19患者与匹配的流感患者和未感染的对照.
- 主要结局是AIRD的发病,通过ICD-10代码识别,在感染后1,6和12个月或匹配的索引日期.
主要成果:
- 与未感染的对照组 (aHR,1.25) 和流感感染的患者 (aHR,1.30) 相比,COVID-19患者在感染后30天内出现事件AIRD的风险增加.
- AIRD的风险与急性COVID-19的严重程度有显著的相关性.
- 在韩国和日本队伍中也观察到类似的结果.
结论:
- SARS-CoV-2 感染与发生自身免疫性炎症性类风湿性疾病的风险增加有关.
- 急性COVID-19的严重程度与发展AIRDs的更高风险相关.
- 这些发现突出了COVID-19的潜在的长期风湿后果.
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