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Updated: Jul 1, 2025

Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy
06:51

Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy

Published on: December 17, 2019

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针对TNF/IAP途径与T细胞急性淋巴细胞白血病的抗CD3免疫疗法协同作用

Andrea Ávila Ávila1,2,3,4,5, Kanokporn Nuantang1,2,3,4,5, Mariana L Oliveira1,2,3,4,5

  • 1Institut Curie, Orsay, France.

Blood
|March 4, 2024
PubMed
概括

用抗CD3单克隆抗体 (mAbs) 向T细胞受体 (TCR) 显示出对T细胞急性淋巴细胞白血病 (T-ALL) 的承诺. 将抗CD3mAbs与TNF抑制剂或SMAC模拟剂结合起来,可以增强抗白血病效应,并改善T-ALL模型中的存活率.

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