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双侧冠状腺分离随后的小说化学抗原受体T细胞免疫疗法方案

Timothy J Goblirsch¹, Vincent Huang, Albert Maguire

¹Department of Ophthalmology, University of Pennsylvania Scheie Eye Institute, Philadelphia, Pennsylvania.

Retinal cases & brief reports

|March 4, 2024

概括

一种用于转移性前列腺癌的新型免疫疗法在患者身上引起了视力威胁的双边胆道脱落. 及时的类固醇治疗导致症状和临床改善,强调需要密切监测.

科学领域:

在瘤学瘤学.
免疫治疗是一种免疫疗法.
眼科医生眼科眼科

背景情况:

转移性前列腺癌带来了重大的治疗挑战.
新型免疫疗法,如仿真抗原受体T细胞疗法,提供了新的治疗途径.
与新型癌症疗法相关的不良事件需要详细的文档.

研究的目的:

报告与新型化学抗原受体T细胞免疫疗法相关的视力威胁不良事件.
描述接受这种免疫疗法的患者胆道脱落的临床表现和管理.

主要方法:

观察情况报告.
详细的眼科检查,包括光学连贯性断层扫描和B扫描超声波.
临床监测患者对治疗的反应.

主要成果:

一名77岁的男性患者在接受转移性前列腺癌的奇默抗原受体T细胞免疫疗法后,出现了双边广泛的胆道脱落.
眼科影像检查证实了胆道脱而没有视网膜脱或视网膜内/视网膜上液体.
在开始局部和全身类固醇治疗后,患者经历了症状和临床改善.

结论:

双边胆膜脱落可能是新型免疫疗法系统反应的罕见副作用.
系统性和局部类固醇是这种免疫疗法诱导的眼睛并发症的有效治疗方法.
建议对接受新型免疫治疗方案的患者进行密切的眼科随访.

关键词:

双边冠状腺脱落.癌症免疫疗法免疫疗法血清性冠状腺输出.

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