视觉效果在内部限制后,膜剥离,而不是在完全厚度毛孔的关闭中折叠
Mallory K Suarez1, Sean K Wang1, Bartlett Hayes1
1Department of Ophthalmology, Wake Forest School of Medicine, Winston-Salem, North Carolina; and.
Retina (Philadelphia, Pa.)
|March 4, 2024
概括
内部限制膜剥离 (ILMP) 和片 (ILMF) 在关闭黄斑孔方面表现出类似的成功. 然而,ILMP在术后的伪眼中提供了优越的视觉敏度.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜外科手术 视网膜外科手术
背景情况:
- 全厚黄斑孔 (FTMH) 是视力丧失的重要原因.
- 手术关闭FTMH的目的是恢复视觉功能.
- 内部限制膜 (ILM) 操纵是FTMH修复的一个关键步骤.
研究的目的:
- 为了比较内部限制膜剥离 (ILMP) 与内部限制膜 (ILMF) 的术后结果,用于FTMH关闭.
- 为了评估两种技术之间的孔闭率和视觉敏度的差异.
主要方法:
- 以后回顾的FTMH患者的图表审查,这些患者接受了用ILMP或ILMF进行的帕斯普拉纳视切除术.
- 从2012年1月到2022年10月收集的数据,至少需要3个月的随访时间.
- 主要结果指标: logMAR.中的FTMH闭合率和最佳校正视敏度 (BCVA).
主要成果:
- 130只眼睛接受了ILMP,30只眼睛接受了ILMF,没有显著的基线差异.
- 高初级孔关闭率:ILMP的96%和ILMF的90% (P=0.29).
- 在成功关闭的伪眼中,ILMP导致1年后优异的BCVA (0.42 logMAR) 与ILMF (0.71 logMAR) 相比.
结论:
- 无论是ILMP还是ILMF技术,都实现了高的FTMH关闭率.
- 当FTMH成功关闭时,ILMP在伪光眼中显示出优异的视觉结果,与ILMF相比.
相关概念视频
01:32Pinching-off of Coated Vesicles
3.1K
Vesicle budding is orchestrated by distinct cytosolic proteins such as adaptor proteins, coat proteins, and GTPases. To initiate vesicle budding, membrane-bending proteins containing crescent-shaped BAR domains bind to the lipid heads in the bilayer and distort the membrane to form a protein-coated vesicle bud. Adaptors proteins such as AP2 for clathrin-coated vesicles can nucleate on the deformed membrane. Finally, coat proteins such as clathrin or COPI and COPII assemble into a coat forming...
3.1K
01:28Types of Membrane Protrusions
3.0K
The protrusion of the cell surface is an initial step for several cellular processes, including cell migration, phagocytosis, and neurite outgrowth. These membrane protrusions are a result of cytoskeletal rearrangement. The most widely observed cell protrusions include lamellipodia, pseudopodia, filopodia, microvilli, invadopodia, and podosomes. These protrusions can be of two types — static or dynamic.
The microvilli, an example of stable protrusions, are finger-like projections...
The microvilli, an example of stable protrusions, are finger-like projections...
3.0K
01:17Accessory Structures of the Eye
4.3K
Optical perception, or vision, is an extraordinary sense dependent on converting light signals received via the ocular organs. These organs, known as eyes, are securely positioned within the bony cavities of the skull, called orbits. The orbits serve a dual purpose: a protective shield for the ocular globes and a stable attachment point for the soft ocular tissues. The eye's external protective mechanisms include the eyelids, which are edged with lashes that act as a barrier against foreign...
4.3K