免疫瘤治疗的并发症:泌尿科医生应该知道什么
Valentina Grajales1, Alberto Martini1, Neal D Shore2
1University of Texas MD Anderson Cancer Center, Houston, TX, USA.
BJU international
|March 4, 2024
概括
免疫相关的不良事件 (irAEs) 是尿瘤学的关键考虑因素. 对于泌尿科医生来说,了解和管理这些事件至关重要,因为免疫疗法在治疗泌尿癌症方面越来越广泛.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 免疫疗法,特别是免疫瘤学 (IO) 化合物,已经改变了癌症治疗.
- IO疗法越来越多地用于尿道癌,脏癌和前列腺癌等尿道恶性瘤,产生显著的反应.
研究的目的:
- 在泌尿瘤学中提供免疫相关不良事件 (irAEs) 的实用审查.
- 为泌尿科医生提供知识,以便在接受免疫治疗的患者中管理irAEs.
主要方法:
- 进行了一次文献综述.
- 分析了在泌尿瘤患者中报告irAEs的研究,重点是对执业泌尿科医生的相关性,直到2023年9月.
主要成果:
- 免疫疗法彻底改变了泌尿癌的治疗方法,显示了持久的反应.
- 泌尿科医生必须准备好理解,评估和治疗irAEs.
- 新兴的研究正在探索在尿瘤疾病早期阶段的免疫治疗.
- 报告指出,IREs与改善的瘤结果之间存在潜在的关联.
结论:
- 免疫相关的不良事件 (irAEs) 可能是严重的,可能危及生命,可能需要长期管理.
- 对与新型免疫治疗剂相关的毒性有全面的了解,对于有效的患者护理至关重要.
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