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结构微环境赋予胰腺神经内分泌瘤具有特定的侵入性和转移性表型

Zeng Ye1, Qiang Li2, Yuheng Hu1

  • 1Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, 200032, China; Center for Neuroendocrine Tumors, Fudan University Shanghai Cancer Center, Shanghai, 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China; Shanghai Pancreatic Cancer Institute, Shanghai, 200032, China; Pancreatic Cancer Institute, Fudan University, Shanghai, 200032, China.

Cancer letters
|March 4, 2024
PubMed
概括

与癌症相关的纤维细胞 (CAFs) 驱动胰腺神经内分泌瘤的瘤生长和转移. 肌纤维细胞CAF通过TGF-β信号传递促进表皮细胞-介质细胞过渡 (EMT) 和肝转移.

关键词:
细胞相互作用 细胞相互作用空间异质性 空间异质性瘤细胞的可塑性在瘤中,瘤流体 (stroma) 形成.

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