在常规试管婴儿程序中累积使用的一次性消耗品可能会表现出毒性
Lucie Delaroche1,2, Lucile Besnard2, Valérie Ouary3
1Ramsay Santé, Hôpital Privé de Parly 2, Institut Fertilité Maternité Parly 2, Le Chesnay-Rocquencourt, France.
Human reproduction (Oxford, England)
|March 4, 2024
概括
结合体外受精一次性产品的累积毒性可能会损害精子的运动性. 单独测试消耗品会忽略这种风险,强调需要进行组合测试以确保生殖技术安全.
科学领域:
- 生殖医学 生殖医学
- 毒理学 毒理学 毒理学
- 在体外受精 (IVF)
背景情况:
- 试管婴儿消耗品可能含有影响人类胚胎发育的成分.
- 目前对IVF一次性产品的毒性查是单独进行的.
- 在试管婴儿中连续使用多种设备可能会导致累积化学物质暴露.
研究的目的:
- 用人类精子运动性测试 (HSMA) 来评估顺序使用的试管婴儿一次性产品的累积毒性.
- 评估非有毒单个消耗品的组合是否表现出毒性.
主要方法:
- 使用HSMA方法的观察性研究从2021年3月到2022年10月.
- 单独和组合测试了14种类型的试管婴儿消耗品 (3, 4 和 5 个项目).
- 定义的毒性值是精子运动指数 (SMI) 在三个测试中的至少两个测试中低于0.85.
主要成果:
- 虽然92%的单一一次性产品符合标准,但8%显示有毒性.
- 在48种 (35%) 之前无毒的消耗品组合中,有17种组合表现出有毒性.
- 随着使用的耗材数量 (P=0.013),累积毒性风险显著增加 (P=0.013).
结论:
- 试管婴儿一次性产品的个人毒性测试是不够的.
- 联合一次性产品的累积毒性对精子运动有风险.
- 建议合理化消耗品的数量,并重新评估试管婴儿中玻璃的使用.
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