脑下垂体副腹腔刺激通过氧化素传递抑制了无感受性宽动态范围的三宫复合细胞
Miguel Condés-Lara1, Guadalupe Martínez-Lorenzana1, Antonio Espinosa de Los Monteros-Zúñiga1
1Instituto de Neurobiología, Universidad Nacional Autónoma de México, Querétaro CP 76230, México.
概括
催产素信号传递通过催产素受体 (OTR) 抑制脑干中的疼痛信号. 这项研究揭示了催产素.
科学领域:
- 神经科学是一个神经科学.
- 疼痛研究 疼痛研究
- 神经内分泌学神经内分泌学
背景情况:
- 催产素传递通过催产素受体 (OTR) 在多个神经系统水平调节 nociception.
- 从下丘脑侧心室核 (PVN) 到脊髓和三角核尾部 (Sp5c) 存在一条通路.
- 三角椎综合体 (TCC) 与面疼痛 (例如偏头痛) 有关,但氧化在这方面的作用尚未得到充分研究.
研究的目的:
- 调查催化素传递在调节TCC内的 nociception中的作用.
- 探索神经元通路和细胞机制,参与催产素在TCC中抑制疼痛的作用.
主要方法:
- 在雄性Wistar大鼠中,TCC宽动态范围 (WDR) 细胞的体内电生理记录.
- 围绕轨道或脑膜区域的电刺激,以唤起神经元的激发.
- 利用神经元标记物 (-鲁比,真蓝,-金) 和OTR对手来绘制路径并评估抑制.
主要成果:
- 通过PVN电刺激,可以减少TCC WDR电池的触发,而这种触发是由外围刺激引起的.
- 这种抑制被局部OTR抗剂逆转,证实了OTR的参与.
- 观察到从PVN到TCC WDR细胞的神经元投射,OTR与色素基因相关 (CGRP) 和GABA附近的同位化.
结论:
- 内源性催产素性传播抑制了TCC中的感觉活性.
- 这种抑制通过第二阶神经元的OTR激活发生,可能涉及CGRPergic和GABAergic通路.
- 研究结果表明,催产素可能成为治疗面疼痛障碍的治疗标.
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