在心力衰竭中,心上脂肪组织和心周约束与保存的喷射分数存在心力衰竭
Yoran Crum1, Elke S Hoendermis1, Dirk J van Veldhuisen1
1Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, PO Box 30.001, Groningen, The Netherlands.
ESC heart failure
|March 4, 2024
概括
肥胖和心表脂肪组织 (EAT) 与心脏衰竭中的心脏限制有关,心脏衰竭具有保存的喷射分数 (HFpEF). 这表明EAT可能会影响HFpEF血液动力学,这需要进一步调查.
科学领域:
- 心脏病学 心脏病学
- 心血管生理学心血管生理学
- 医疗成像医学成像
背景情况:
- 肥胖和上心脂肪度与心力衰竭的病理生理学有关,其中包括保留喷射分数 (HFpEF).
- 这些情况与HFpEF患者的填充压力升高和运动能力降低有关.
- 这些关联背后的精确血液动力学机制仍然不完全理解.
研究的目的:
- 调查假设,心周囊内心上脂肪组织 (EAT) 的增加与心周约束的血液动力学指标有关.
- 探索 EAT 和 HFpEF 中特定的血液动力学参数之间的关系.
主要方法:
- 包括HFpEF患者同时接受入侵性心脏导管和心声回声.
- 侵入性测量右心房压力 (RAP),右心室末端透气压力和肺毛细血管压力 (PCWP).
- 使用右心室压力波形上的平方根符号和RAP/PCWP比率来评估心周约束.
- 对EAT厚度进行心声回声测量.
主要成果:
- 在64名被研究的患者中,有73%的患者出现了方根符号,表明心周约束.
- 平方根符号的存在与更高的体重指数 (BMI),更大的EAT厚度和升高的RAP相关.
- 与男性相比,女性表现出更高的EAT和EAT,RAP和心周约束指标之间的更强的关联.
结论:
- 在HFpEF中,肥胖和心上脂肪与心周约束的血液动力学迹象有关.
- 这些发现表明EAT在HFpEF中观察到的血液动力学变化中的潜在作用.
- 需要进一步的研究来阐明这些关联的病理生理和治疗影响.
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