黑素不能降低住院老年人痴呆症的严重程度:一个随机的安慰剂对照试验的结果
Peter W Lange1,2, Alisa Turbić3, Cheng Hwee Soh1
1Department of Aged Care and Medicine, The Royal Melbourne Hospital, Melbourne Medical School, The University of Melbourne, Parkville, Victoria, Australia.
Journal of the American Geriatrics Society
|March 4, 2024
概括
这项研究发现,梅拉宁在老年住院患者中并没有显著降低痴呆症的严重程度. 然而,梅拉宁可能会缩短住院时间,这需要进一步调查.
科学领域:
- 老年医学 老年医学
- 药理学 药理学是指药理学的学科.
- 关键护理医学 关键护理医学
背景情况:
- 痴呆症是老年住院患者中普遍存在的严重疾病,与不良结果有关.
- 目前的 Delirium 治疗方法受到有效性和副作用的限制,这凸显了对新型治疗策略的需求.
- 在妄想中观察到睡眠-清醒周期和黑激素水平的中断,这表明黑激素补充剂可能起作用.
研究的目的:
- 评估口服メラトニン (5毫克即时释放每晚五晚) 在老年医疗住院患者中减轻妄想严重性的疗效.
- 评估黑素对纪念狂妄症评估量表 (MDAS) 评分的影响.
主要方法:
- 在一般内科病房进行了一项双盲随机对照试验.
- 参与者包括老年人 (≥65岁) 患有过度活跃或混合妄想,使用混乱评估方法进行评估.
- 主要结局是MDAS测量的狂妄症严重程度的变化,120名参与者随机分配给梅拉托宁或安慰剂.
主要成果:
- 梅拉托尼组 (4.9) 和安慰剂组 (5.4) (p=0.42) 之间,MDAS得分的平均降低没有显著差异 (p=0.42).
- 参与者可以很好地容忍黑素.
- 后期分析表明,与安慰剂组 (10天) 相比,黑色素组的停留时间较短 (9天) (p=0.033).
结论:
- 这项研究没有支持梅拉宁可以降低老年医疗住院患者痴呆症的严重程度的假设.
- 对非显著发现的潜在解释包括没有真正的影响,效果小于预期,或评估尺度的局限性.
- 建议进行进一步的研究,以探索黑素在减少逗留时间方面的潜在益处.
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