基于对批发发酵过程的反事实推断的错误诊断
1Key Laboratory of Advanced Process Control for Light Industry (Ministry of Education), Jiangnan University, Wuxi 214122, China.
ISA transactions
|March 4, 2024
概括
这项研究引入了一种用于批量发酵的新型故障检测和诊断方法. CNN-VAE模型提高了故障检测的效率和准确性,而FDCI则确定了故障来源.
科学领域:
- 工业过程控制 工业过程控制
- 机器学习应用 机器学习应用
- 生物技术是生物技术.
背景情况:
- 有效的故障诊断对于工业流程至关重要,但目前的方法在批量发酵中难以评估故障幅度和效率.
- 现有的技术往往缺乏对复杂的生物系统 (如L. plantarum发酵) 所需的精度.
研究的目的:
- 为批量发酵过程开发先进的故障检测和诊断模型.
- 解决评估故障幅度的局限性,提高诊断效率.
主要方法:
- 利用相互信息 (MI) 进行与质量相关的过程变量选择.
- 采用基于变异自编码器 (CNN-VAE) 的卷积神经网络进行故障检测.
- 开发了基于反事实推断 (FDCI) 的故障诊断,用于根源原因分析.
- 从CNN-VAE模型的潜伏和残余域构建了两个统计数据.
主要成果:
- 拟议的CNN-VAE模型有效地检测过程数据中的故障.
- FDCI成功地识别了检测到故障的根本原因.
- 该方法在模拟和现实世界L. plantarum批发发酵过程中表现出高效率.
结论:
- 综合CNN-VAE和FDCI方法为批量发酵中的故障检测和诊断提供了强大的解决方案.
- 该方法通过提供故障幅度见解和提高效率来改进现有技术.
- 该研究验证了该模型在复杂的生物技术过程中的适用性.
更多相关视频
12:47Workflow Based on the Combination of Isotopic Tracer Experiments to Investigate Microbial Metabolism of Multiple Nutrient Sources
Published on: January 22, 2018
9.4K
07:15An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota
Published on: July 31, 2019
9.6K
相关概念视频
Microbial Fermentation
1.8K
Fermentation is a crucial anaerobic metabolic process that enables microbes to derive energy from sugar without relying on oxygen or an electron transport chain. This process is fundamental to various biological and industrial applications and is classified based on the metabolic products generated.Role of Pyruvate in FermentationPyruvate and its derivatives serve as key electron acceptors in fermentative pathways. The oxidation of NADH to regenerate NAD+ is essential for the continuation of...
1.8K
Microbes in Food Production
407
Microbial fermentation is central to food biotechnology, enhancing flavor, texture, preservation, and stability. Fermentative microorganisms metabolize carbohydrates into organic acids, alcohols, and other metabolites that inhibit spoilage organisms and improve digestibility while contributing distinctive sensory qualities.In baking, amylases naturally present in flour hydrolyze starch into monosaccharides such as glucose, which Saccharomyces cerevisiae ferments anaerobically. Through...
407
Microbes in Beverage Production
300
Alcoholic beverages such as wine, beer, and spirits are the products of microbial fermentation processes that transform simple sugars into ethanol and a wide array of complex flavor compounds. These transformations rely on the metabolic activities of specific yeasts and bacteria, which are selected and controlled to yield the desired beverage characteristics.Wine Fermentation and MaturationWine production begins with the crushing of grapes to release juice and pulp, forming a must that is...
300
Bioreactor Controls-I
103
Maintaining optimal conditions within fermenters is essential for maximizing microbial productivity and ensuring process efficiency. This lesson focuses on key parameters—temperature, foam, pH, carbon dioxide, oxygen, and pressure—and their precise measurement and control strategies in fermentation systems.Temperature ControlTemperature regulation is critical due to the exothermic nature of many fermentation processes. In small laboratory fermenters, temperature is commonly...
103
Batch vs Continuous Culture
246
Fermentation is a foundational biotechnological process used to produce pharmaceuticals, biofuels, enzymes, and food additives. Among industrial strategies, batch and continuous fermentation are the two most widely applied. Although both rely on microbial conversion of substrates into desired products, they differ markedly in operation, productivity, and suitability for specific applications.Batch fermentation occurs in a closed system in which nutrient media and inoculum are added at the...
246
Fed-Batch Culture
187
Fed-batch culture is a widely used bioprocessing strategy combining aspects of batch culture with controlled substrate feeding to optimize cell growth and product formation. In this semi-closed system, nutrients are strategically added during fermentation, while the accumulated products and biomass remain within the bioreactor until the end of the operation. This controlled addition of substrates allows for better management of growth kinetics, nutrient limitation, and metabolite...
187
