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Updated: Jul 1, 2025

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一种TNBC选择性细胞毒性和诺尔-埃莫菲兰,PC-A的总合成及其初步的结构-活动关系

Sayaka Maeda1, Wakana Nakayama1, Yohei Saito1

  • 1School of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, 920-1192, Japan.

Journal of natural products
|March 4, 2024
PubMed
概括

研究人员合成了PC-A,这种化合物对三阴性乳腺癌 (TNBC) 具有选择性活性. 这项工作使得进一步研究结构-活性关系,以开发新的癌症治疗方法成为可能.

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Radical Substitution: Allylic Bromination

In organic synthesis, the formation of products can be altered by changing the reaction conditions. For example, a dibromo addition product is formed when propene is treated with bromine at room temperature. In contrast, propene undergoes allylic substitution in non-polar solvents at high temperatures to give 3-bromopropene. In order to avoid the addition reaction, the bromine concentration must be kept as low as possible throughout the reaction. This can be achieved using N-bromosuccinimide...
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