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Updated: Jul 1, 2025

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一个非正规的核友解锁了一个新的机械路径在一个设计的酶

Amy E Hutton1, Jake Foster1, Rebecca Crawshaw1

  • 1Manchester Institute of Biotechnology, School of Chemistry, The University of Manchester, Manchester, UK.

Nature communications
|March 4, 2024
PubMed
概括

设计酶的定向进化揭示了莫里塔-贝利斯-希尔曼 (MBH) 反应的新途径. 用Nδ-methylhistidine取代histidine,通过启用一种新的质子转移机制,创造了一个高度活性的酶.

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