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Updated: Jul 1, 2025

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丁三酸盐合成酶1的非激活可以防止小鼠发生致命的自身免疫

Claire Soudais1,2, Romane Schaus3, Camille Bachelet3,4

  • 1Laboratory of Lymphocyte Activation and Susceptibility to EBV infection, Inserm UMR 1163, Institut Imagine, Paris, France. claire.soudais@inserm.fr.

Nature communications
|March 4, 2024
PubMed
概括

丁三酸盐合成酶1 (CTPS1) 对于免疫细胞生长和存活至关重要. CTPS1 缺乏导致胚胎死亡,但其在T细胞中的向删除可以治疗自身免疫性疾病.

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Inhibition of Cdk Activity02:34

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The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
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