衰老和脆弱对循环单细胞和树突细胞子集的影响
Rosanne D Reitsema1,2, Ashok K Kumawat2, Bernd-Cornèl Hesselink1
1Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, The Netherlands.
npj aging
|March 4, 2024
概括
像树突细胞 (DC) 和单细胞这样的免疫细胞随着年龄的增长而发生变化,影响性. 老年人的虚弱与这些免疫细胞的特定变化有关,可能导致炎症.
科学领域:
- 免疫学 免疫学 免疫学
- 老年学是一门学科.
- 细胞生物学 细胞生物学
背景情况:
- 老龄化导致免疫失调,增加感染易感性和慢性炎症 (炎症).
- 虚弱,老年人的健康状况下降和身体损伤,与免疫系统的变化有关.
- 单细胞和树突细胞 (DCs) 是启动和指导免疫反应的关键免疫细胞.
研究的目的:
- 研究衰老和脆弱对血液中单细胞和DC子集的频率和表型的影响.
- 为了比较健康的年轻对照,健康的老年对照和脆弱的老年人之间的免疫细胞概况.
主要方法:
- 流细胞计用于分析血液样本中的单细胞和DC子集.
- 参与者包括健康的年轻人 (HYC),健康的老年人 (HOC) 和脆弱的老年人.
- 确定了单细胞子集 (经典,中间,非经典) 和DC子集 (cDC1,cDC2,pDC),并评估了它们的标志物表达 (TLR2,TLR4,HLA-DR,CD86,PDL1,CCR7,CD40).
主要成果:
- 与HYC相比,在HOC中观察到的血类树突细胞 (pDC) 的比例较低.
- 经典和中间单细胞和cDC2在HOC和HYC中表达了激活标记的更高表达.
- 与HOC相比,脆弱个体在古典和非古典单细胞上表现出较高的CD40表达.
结论:
- 衰老显著影响单细胞和DC群体,pDCs减少可能会损害病毒反应.
- 单细胞和cDC2上的激活标记表达增加表明有助于炎症.
- 在脆弱个体中CD40的升级需要进一步研究其功能影响.
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