结构连接体的遗传架构
Michael Wainberg1,2,3,4, Natalie J Forde5, Salim Mansour6
1Krembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, Toronto, ON, Canada. m.wainberg@utoronto.ca.
Nature communications
|March 4, 2024
概括
遗传学显著影响大脑的电线. 全基因组关联研究揭示了30种基因变异影响髓质轴突连接,将它们与大脑发育和功能联系起来.
科学领域:
- 神经遗传学 神经遗传学
- 在Connectomics上,我们提供了连接.
- 神经成像是一种神经成像.
背景情况:
- 长距离的髓连接对于快速的大脑通信至关重要.
- 结构性大脑连接的遗传基础在很大程度上是未知的.
- 了解遗传控制是解读大脑组织和功能的关键.
研究的目的:
- 为了研究结构性大脑连接的遗传结构.
- 识别与白质通道密度和组织相关的遗传变异.
- 探索神经发育路径和遗传影响对连接性的功能影响.
主要方法:
- 来自英国生物库扩散MRI通道图的206个结构连接度的全基因组关联研究 (GWAS) (N=26,333).
- 包括Bonferroni校正在内的统计分析,以确定全基因组显著变异.
- 分析与神经精神和认知特征的遗传相关性,并在特定细胞类型中丰富遗传性.
主要成果:
- 确定了与结构连接相关的30个独立的全基因组显著变异.
- 涉及的基因涉及髓化,神经元引导,细胞增殖,迁移,细胞骨组织和金属运输.
- 证明结构连接具有高度多基因性,空间结构,并且与神经精神和认知特征有遗传相关性.
结论:
- 白物质连接的普遍的,热的和空间结构的遗传控制存在.
- 对连接性的遗传影响是由多种神经发育途径介导的,包括髓化和早期大脑发育.
- 这些发现凸显了结构连接的遗传控制对健康的大脑功能和神经精神疾病的相关性.
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