后COVID-19综合征的认知衰退与持续的神经元或星球细胞损伤不相对应
Fabian Boesl1, Yasemin Goereci2, Finja Schweitzer2
1Department of Neurology, Charité-University Medicine Berlin, Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Hindenburgdamm 30, 12203, Berlin, Germany. fabian.boesl@charite.de.
Scientific reports
|March 4, 2024
概括
在COVID-19 (PCS) 后的认知障碍可能不会源于持续的神经元或星球细胞损伤. 像神经丝轻链 (NfL) 和状纤维酸蛋白 (GFAP) 这样的生物标志物与PCS患者的认知缺陷没有相关性.
科学领域:
- 神经学 神经学
- 神经科学是一个神经科学.
- 传染性疾病 传染性疾病
背景情况:
- 认知障碍是COVID-19后综合征 (PCS) 的一个常见症状.
- 与PCS相关的认知功能障碍的根本原因尚不清楚.
- 神经纤维光链 (NfL) 和状纤维酸蛋白 (GFAP) 是神经损伤的潜在生物标志物.
研究的目的:
- 为了调查NfL和GFAP的血清水平作为神经元和神经细胞损伤的指标,在PCS患者认知投诉.
- 通过神经心理评估 (NPA) 评估认知障碍的严重程度,将这些生物标志物水平与这些认知障碍的严重程度相关联.
主要方法:
- 在报告认知问题的53名PCS患者中测量了血清NfL和GFAP水平.
- 患者接受了全面的神经心理评估 (NPA),并根据认知能力下降被分为分组.
- 进行了统计分析,以评估生物标志物水平和认知功能之间的相关性,根据年龄进行调整.
主要成果:
- 所有患者的血清NfL水平都在正常范围内.
- 在4%的患者中检测到血清GFAP的轻微增加.
- 血清NfL和GFAP水平显示出与年龄无关的显著相关性 (r=0.347,p=0.012).
- 在70%的患者中,NPA揭示了认知缺陷,其中40%的患者经历了多领域障碍.
- 在不同程度的认知衰退的子组中,没有观察到NfL或GFAP水平的显著差异.
结论:
- 根据NfL和GFAP水平,持续的神经元或星细胞损伤似乎与COVID-19后综合征的认知障碍没有直接相关.
- 需要进一步的研究来阐明PCS认知功能障碍背后的机制.
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