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对多种金属的联合暴露对腹腔大动脉化的影响:来自NHANES研究的结果

Yuan-Hang Zhou^1,2, Yu-Jie Bai³, Xiao-Yan Zhao^4,5

¹Department of Cardiology, Cardiovascular Center, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.

Environmental science and pollution research international

|March 4, 2024

概括

暴露于多种金属,包括,,和,增加了美国40岁以上成年人的腹腔大动脉化 (AAC) 风险. 在肥胖,吸烟或饮酒的人群中,这种风险会增加.

科学领域:

环境健康环境健康
毒理学毒理学毒理学
心血管流行病学心血管流行病学

背景情况:

暴露于金属是与各种疾病相关的日益严重的公共卫生问题.
关于金属混合物对腹腔大动脉化 (AAC) 的影响的研究是有限的.
了解合金效应对于公共卫生风险评估至关重要.

研究的目的:

调查多重金属暴露与AAC风险之间的关联.
确定导致AAC风险的关键金属组件.
探索金属-AAC关系中的潜在改变因素.

主要方法:

对838名美国成年人 (年龄≥40岁) 尿液中的14种金属进行分析.
使用了通用线性回归,加权量子式总回归 (WQS),量子式g计算 (Qgcomp) 和贝叶斯内核机器回归 (BKMR) 模型.
根据相关的共变量进行调整,并进行子组分析.

主要成果:

(Cd) 显示出与AAC风险的积极关联,而 (Co) 在后勤回归中显示出负相关性.
WQS,Qgcomp和BKMR模型表明,整体金属混合物暴露与AAC风险之间存在显著的积极关联.
确定了 (Cd), (Pb), (U) 和 (W) 作为积极关联的主要贡献者.
在BMI≥25kg/m2的参与者,腹部肥胖,以及饮酒或吸烟者中,相关性更强.

结论:

对多种金属,特别是Cd,Pb,U和W的联合暴露会增加40岁及以上美国成年人AAC的风险.
肥胖,吸烟和饮酒加剧了与金属暴露相关的风险.
研究结果强调,需要制定公共卫生战略,以减轻金属暴露及其心血管后果.

关键词:

腹腔大动脉化腹腔大动脉化 BKMR BKMR BKMR BKMR BKMR BKMR BKMR BKMR BKMR BKMR BKMR BKMR BKMR BKMR 金属金属金属金属在Qgcompcomp中使用Qgcomp.在WQS中,WQS就是WQS.

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