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Updated: Jul 1, 2025

Establishment and Characterization of Three Afatinib-resistant Lung Adenocarcinoma PC-9 Cell Lines Developed with Increasing Doses of Afatinib
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Establishment and Characterization of Three Afatinib-resistant Lung Adenocarcinoma PC-9 Cell Lines Developed with Increasing Doses of Afatinib

Published on: June 26, 2019

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在RET驱动的癌症中,适应性达尔文的目标外耐药机制对选择性RET抑制产生了选择性RET抑制

Vivek Subbiah1,2, Mohamed A Gouda3, J Bryan Iorgulescu4

  • 1Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Vivek.Subbiah@scri.com.

NPJ precision oncology
|March 4, 2024
PubMed
概括

在甲状腺髓癌中对RET氨酸激酶抑制剂 (TKIs) 的耐药性可以通过组合疗法克服. 针对获得的NTRK和ALK融合以及RET突变,提供了个性化的治疗策略.

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Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms08:46

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Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down08:59

Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down

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