初级侧面硬化症中的上下垂体退化模式:多式纵向神经放射学研究
Jana Kleinerova1, Marlene Tahedl1, Ee Ling Tan1
1Computational Neuroimaging Group (CNG), School of Medicine, Trinity College Dublin, Dublin 2, Ireland.
Journal of neurology
|March 4, 2024
概括
主要侧面硬化症 (PLS) 不仅涉及上部运动神经元问题,还显示小脑缩和大脑连接的改变. 这种广泛的神经退行影响运动功能和认知症状.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 神经成像是一种神经成像.
背景情况:
- 主要侧面硬化症 (PLS) 传统上表现为上部运动神经元功能障碍,包括性和步行障碍.
- 新出现的证据表明,在一些PLS患者中,前功能障碍和认知缺陷存在.
- 尽管有一些病例报告,PLS中的小脑病理仍然不太了解.
研究的目的:
- 纵向描述PLS.中脑内疾病负担的演变.
- 评估PLS患者随时间变化的脑-小脑连接的变化.
- 在PLS中调查神经退行症超出主要运动区域的程度.
主要方法:
- 一项纵向神经成像研究,涉及43名PLS患者.
- 评估深层小脑核和小脑皮层体积.
- 通过扩散和功能性MRI评估大脑-小脑结构和功能连接.
主要成果:
- 基线研究结果显示,大脑与小脑之间存在广泛的结构性和功能性断裂,包括大脑与前脑,脑,脑,脑,脑和脑的途径.
- 在虫,叶片和背部牙核中观察到显著的小脑体积减少.
- 还检测到主要运动皮层的缩和跨层退化,尽管纵向进展在统计学上并不显著.
结论:
- PLS的特征是小脑皮层体积损失和深小脑核缩,延伸到最初的上部运动神经元功能障碍之外.
- 在PLS中,大脑-小脑连接的改变是显而易见的,这表明神经退行症的广泛传播.
- 在PLS中,小脑功能障碍可能会导致运动障碍 (腹筋,步态,灵敏度) 和情感症状.
相关概念视频
01:19Multiple Sclerosis l: Introduction
Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
01:25Secondary Spinal Cord Injury llI: Pathophysiology
Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...