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在肝细胞癌中,内细菌与代谢扭曲之间的相互作用

Chen Xue¹, Xinyu Gu², Qingmiao Shi¹

¹State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.

Journal of translational medicine

|March 4, 2024

概括

内细菌及其代谢物与肝细胞癌 (HCC) 有关. 这项研究揭示了HCC组织中独特的微生物和代谢概况,为这种癌症提供了潜在的生物标志物和治疗点.

科学领域:

微生物学微生物学
在瘤学瘤学.
代谢学代谢学代谢学

背景情况:

内细菌与各种癌症有关,但它们在肝细胞癌 (HCC) 中的作用尚不清楚.
了解瘤微生物组与宿主之间的相互作用对于推进癌症研究至关重要.

研究的目的:

为了研究HCC中内细菌的特征.
探索HCC组织的代谢概况及其与瘤微生物组的关联.
根据微生物和代谢变化来确定HCC的潜在生物标志物和治疗点.

主要方法:

在HCC组织中检测细菌16SrRNA和脂聚糖 (LPS) 使用光 in situ杂交和免疫组织化学.
使用Hepa1-6细胞建立 ортотопHCC小鼠模型.
通过2bRAD测序和使用液态染色体质谱的代谢概况分析内细菌组成.

主要成果:

在人体样本和小鼠模型中,在HCC组织和相邻的非瘤组织之间观察到内细菌的显著差异.
在HCC组织中发现了不同的代谢物,包括N-乙-D-葡萄糖胺和α-乳糖.
特定的细菌,如Pseudomonas koreensis,与某些代谢物,如N-乙-D-葡萄糖胺和素,显示出显著的相关性.

结论:

这项研究证实了特定的内细菌和HCC中的代谢物之间存在强烈的关联.
这些发现表明,开发新的诊断生物标志物和治疗肝细胞癌的治疗策略有新的机会.

关键词:

生物标志物生物标志物肝细胞癌是肝细胞癌.瘤内细菌是一种细菌.代谢物的代谢物.治疗目标治疗目标

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