血栓素1增强了急性-慢性肝衰竭的全身炎症和疾病严重程度
Hozeifa Mohamed Hassan1,2, Xi Liang1, Jiaojiao Xin2
1Precision Medicine Center, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, 318000, China.
BMC medicine
|March 4, 2024
概括
血栓素1 (THBS1) 在急性至慢性肝衰竭 (ACLF) 中被上调,并预测死亡率. THBS1促进炎症和亡,为ACLF提供了潜在的治疗点.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 分子生物学分子生物学
- 生物标志物发现发现
背景情况:
- 在急性至慢性肝衰竭 (ACLF) 病原发生过程中,血素1 (THBS1) 的作用尚不清楚.
- 作为ACLF的潜在生物标志物,THBS1正在被研究.
研究的目的:
- 评估THBS1作为ACLF病变发生的潜在生物标志物.
- 评估THBS1表达与ACLF严重程度和患者结局的相关性.
主要方法:
- 从330名患有不同阶段肝病 (ACLF,肝硬化,慢性乙型肝炎) 和正常对照者的外周血液单核细胞 (PBMC) 的转录组分析.
- 外部验证使用定量聚合酶链反应,酶相关免疫吸收试验,ACLF大鼠模型和肝细胞特异性THBS1淘汰赛小鼠.
主要成果:
- 在ACLF患者中,THBS1显著上调,与疾病严重程度,炎症和肝细胞亡相关.
- THBS1显示出对短期ACLF死亡率的良好预测能力 (AUROC 0.7445-0.8438).
- 在小鼠中,THBS1淘汰改善了生存率,并减少了炎症和亡.
结论:
- THBS1是ACLF发展的潜在生物标志物,与炎症和肝细胞亡有关.
- THBS1可能成为改善ACLF诊断和治疗策略的新型分子标.
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