扩散性心肌纤维化在患有围产期获得的人类免疫缺陷病毒感染的人群中不常见
Jason L Williams1, Frances Hung2, Elizabeth Jenista3,4
1Division of Pediatric Cardiology, Duke University Medical Center, Durham, NC, USA.
AIDS research and therapy
|March 4, 2024
概括
与对照组相比,患有围产期艾滋病毒感染 (pnHIV) 的成年人没有增加心肌纤维化. 需要进一步的研究来评估这一群体的长期心脏结构和功能.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 医疗成像医学成像
背景情况:
- 心血管疾病 (CVD) 是艾滋病毒感染者的主要死亡原因.
- 心肌纤维化是已知的成人艾滋病毒感染的并发症.
- 围产期艾滋病毒感染 (pnHIV) 中纤维化病的患病率尚未得到充分确立.
研究的目的:
- 评估患有围产期艾滋病毒感染的成年人心肌纤维化负担.
- 使用心脏磁共振 (CMR) 来比较PNHIV患者和未感染的对照人群之间的纤维化水平.
主要方法:
- 用本地T1映射的心脏磁共振 (CMR) 来通过细胞外体积分数 (ECV) 评估扩散性纤维化.
- 晚期加多增强被用于评估心肌活力.
- 患有PNHIV的个体 (接受抗逆转录病毒治疗6个月以上) 与未感染的对照进行匹配,不包括具有显著心脏代谢并发症或怀孕的个体.
主要成果:
- 该研究包括14名PNHIV成年人和26名对照,平均年龄为29岁;71%是女性,86%是黑人.
- 人口统计学,CMR功能/体积数据和前对比T1映射值在各组之间相似.
- 在PNHIV组和对照组之间没有发现ECV的统计学上显著差异 (p=0.24),这表明扩散性心肌纤维化没有增加.
结论:
- 周产期获得的艾滋病毒感染与成人扩散性心肌纤维化无关.
- 需要进行更大规模的前性研究,以调查pnHIV患者和对照人群之间心脏结构和功能的潜在长期差异.
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