新生儿中肠道病毒和帕拉埃科病毒脑膜炎:有什么区别?
Simonetta Picone1, Vito Mondì1, Federico Di Palma1
1Neonatology and Neonatal Intensive Care Unit, Policlinico Casilino, Rome, Italy.
Clinical pediatrics
|March 5, 2024
概括
在新生儿中区分肠道病毒 (EV) 和帕雷病毒 (HPeV) 脑膜炎是很有挑战性的,仅仅基于症状. 然而,较高的C反应蛋白 (CRP) 和白细胞 (WBC) 计数可能表明EV感染.
科学领域:
- 新生儿传染病 新生儿传染病
- 儿科神经学 儿科神经学
- 病毒学 病毒学
背景情况:
- 肠道病毒 (EV) 和帕雷病毒 (HPeV) 是常见的新生儿病原体.
- 这两种病毒都是导致婴儿无菌性脑膜炎的主要原因.
- 类似的季节性和临床表现使早期诊断复杂化.
研究的目的:
- 为了比较临床症状,实验室发现,和神经发育结果在婴儿与HPeV对比EV脑膜炎.
- 为了确定区分HPeV和EV脑膜炎的潜在生物标志物.
- 评估临床和实验室参数的诊断实用性,超出脑脊液PCR.
主要方法:
- 10名患有HPeV脑膜炎的婴儿和8名患有EV脑膜炎的婴儿的回顾性比较.
- 分析临床症状,血清C反应蛋白 (CRP),甲,白血细胞 (WBC) 计数和淋巴细胞计数.
- 评估大脑成像 (大脑超声波) 和神经结果.
主要成果:
- 两组之间没有观察到临床表现或神经结果的显著差异.
- 与HPeV患者相比,EV脑膜炎患者的血清CRP,WBC和淋巴细胞值明显较高.
- 在EV和HPeV脑膜炎组中,甲素水平较低.
- 任何一组的婴儿都没有在超声波上表现出脑损伤或负面的神经结果.
结论:
- 仅仅临床症状不足以区分新生儿的HPeV和EV脑膜炎.
- 升高的CRP,WBC和淋巴细胞计数可能表明肠道病毒感染.
- 脑脊液的实时聚合酶链反应 (PCR) 仍然是确定的诊断的黄金标准.
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