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在慢性心力衰竭中,碳水化合物抗原125的度跨射出分数光谱:EMPEROR计划

João Pedro Ferreira^1,2,3, Milton Packer^4,5, Naveed Sattar⁶

¹Department of Surgery and Physiology, Faculty of Medicine of the University of Porto, Cardiovascular Research and Development Center (UnIC@RISE), Porto, Portugal.

European journal of heart failure

|March 5, 2024

概括

碳水化合物抗原125 (CA-125) 不是慢性心力衰竭 (HF) 中拥堵的可靠生物标志物. 然而,CA-125水平升高可能会预测心力衰竭患者的不良结果,减少排气分数 (HFrEF).

科学领域:

心脏病学心脏病学
生物标志物生物标志物
这是心脏衰竭.

背景情况:

血管拥堵是已知的因素,可以提高碳水化合物抗原125 (CA-125) 水平.
慢性心力衰竭 (HF) 中CA-125的预后价值在射出分数 (EF) 谱中尚未得到充分确立.

研究的目的:

调查CA-125与慢性心力衰竭 (HF) 患者的拥堵之间的关联.
评估CA-125作为心血管结果的预后生物标志物,用于不同喷射分数 (EF) 的HF患者.

主要方法:

在1111名来自EMPEROR-Reduced和EMPEROR-Preserved试验的参与者中分析了血清CA-125水平.
考克斯回归模型评估了CA-125三位体与HF住院或心血管死亡的复合结果之间的关系.
在CA-125三角动物中评估了充血症状和症状.

主要成果:

在基线CA-125水平和充血症状之间没有发现显著的关联.
较高的CA-125水平与心力衰竭与减少喷射分数 (HFrEF) 主要结局的风险增加有关,但与保存喷射分数 (HFpEF) 心力衰竭没有相关.
升高的CA-125水平与估计的膜过率的更快下降相关.

结论:

在大多数研究的慢性HF患者中,CA-125不是堵塞的显著生物标志物.
在HFrEF患者中,CA-125可作为HF住院或心血管死亡的预后指标,但在HFpEF患者中并非如此.

关键词:

CA-125 CA-125 是一个简单的 CA-125 类型.交通拥堵拥堵拥堵利尿剂这是一种利尿剂.恩帕格利弗洛辛 (Empagliflozin) 是一种非常重要的药物.心脏衰竭是因为心脏衰竭.功能功能功能

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