脑下骨质细胞和骨关节炎:新的见解和潜在的治疗途径
Wenlong Chen1,2, Qiufei Wang3, Huaqiang Tao3
1Orthopedics and Sports Medicine Center, Suzhou Municipal Hospital, Nanjing Medical University Affiliated Suzhou Hospital, Suzhou 215000, China.
Acta biochimica et biophysica Sinica
|March 5, 2024
概括
骨关节炎 (OA) 涉及到由过度活跃的骨质细胞驱动的亚冠骨变化. 准这些骨质细胞为关节疾病提供了新的治疗策略.
科学领域:
- 生物医学科学 生物医学科学
- 整形外科 整形外科 整形外科
- 细胞生物学 细胞生物学
背景情况:
- 骨关节炎 (OA) 是一种常见的关节疾病,其原因复杂,往往难以有效治疗.
- 在OA中,骨病理在骨病变之前,突出了其关键作用.
- 骨质结晶体是骨再吸收的关键调节体,在OA中,它们是骨下方的骨病原体的核心.
结论:
- 准子冠状腺骨质细胞活动为骨关节炎提供了一个有前途的治疗途径.
- 对这些途径的进一步研究可以导致新的OA治疗临床策略.
- 解决下骨变化对于改善骨关节炎管理结果至关重要.
相关概念视频
01:31Osteoclasts in Bone Remodeling
2.9K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
2.9K
01:19Mesenchymal Stem Cells
4.7K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
4.7K