脑小血管疾病患者中MTHFRC677T多态和认知障碍之间的关联:一个横截面研究
Qijin Wang1, Cuihua Yuan1, Zhixiong Zheng2
1Department of Orthopedics, Affiliated Mindong Hospital, Fujian Medical University, Fuan, China.
Frontiers in aging neuroscience
|March 5, 2024
概括
MTHFR 677 TT基因型与脑小血管疾病 (CSVD) 患者中较严重的白质过强度和认知障碍有关. 这一发现突出了MTHFR基因.
科学领域:
- 神经学 神经学
- 遗传学 遗传学 是一个
- 血管医学 血管医学
背景情况:
- 大脑小血管疾病 (CSVD) 是血管认知障碍的主要原因.
- 在CSVD相关的认知衰退中,MTHFR C677T多态的作用需要进一步研究.
研究的目的:
- 检查MTHFR C677T多态和CSVD患者的认知障碍之间的关联.
- 为了确定白质超强度 (WMH) 和CSVD认知障碍的风险因素.
主要方法:
- 一项涉及330名CSVD患者 (年龄≥45岁) 的横截面研究,符合STRIVE标准.
- 数据收集包括人口统计,病史,认知评估和MTHFR C677T基因定型.
- 使用二进制逻辑回归分析来评估WMH和认知障碍的风险因素.
主要成果:
- MTHFR C677T的TT基因型与更高的同类氨酸水平,更严重的WMH和认知障碍相关 (p < 0.001).
- 多变量分析显示MTHFR基因型是WMH和认知障碍的独立风险因素.
- 在CSVD患者中,WMH和缺陷是认知障碍的显著预测因素.
结论:
- 在CSVD患者中,MTHFR 677 TT基因型是WMH和认知障碍进展的独立风险因素.
- 这种遗传因素可能导致CSVD认知衰退的病理生理学.
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