母乳中的短链脂肪酸及其与婴儿肠道微生物群的关系
Menglu Xi1, Yalu Yan2,3, Sufang Duan2,3
1Vanke School of Public Health, Tsinghua University, Beijing, China.
Frontiers in microbiology
|March 5, 2024
概括
母乳黄油酸 (C4) 影响婴儿的肠道细菌,可能对沙门氏菌等病原体进行保护. 这凸显了C4生产微生物在早期发育中的重要性.
科学领域:
- 微生物学 微生物学
- 人类营养人类营养
- 婴儿健康 婴儿健康
背景情况:
- 母乳中的短链脂肪酸 (SCFA) 对婴儿的生长,新陈代谢和肠道免疫是至关重要的.
- SCFA调节炎症,并在婴儿发育中发挥关键作用.
研究的目的:
- 研究母乳微生物群与SCFA水平之间的关系.
- 探索SCFA如何调节婴儿肠道微生物群.
- 了解SCFA在婴儿免疫和代谢发育中的作用.
主要方法:
- 从50个母婴双体中收集了配对母乳和婴儿便样本.
- 使用UPLC-MS.量化母乳中的SCFA含量.
- 通过全基因组猎枪测序分析了母乳和婴儿便的微生物组成.
- 婴儿肠道微生物群和基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因
主要成果:
- 母乳黄油酸 (C4) 与 *Clostridium leptum* 丰富度正相关.
- 确定了人类牛奶中的*Bifidobacterium*和C4产生细菌之间的潜在共生相互作用.
- 母乳中低C4水平与婴儿中较高的沙门氏菌 (Salmonella) 种类丰度有关.
- 与婴儿代谢路径相关的C4水平,用于lysine和arginine生物合成.
结论:
- 母乳含有共生微生物群,影响婴儿的肠道健康.
- 产生C4的特定牛奶微生物可以影响婴儿的肠道微生物组成和早期发育.
- 母乳SCFA,特别是C4,对于婴儿的免疫和代谢成熟至关重要.
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