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Updated: Jul 1, 2025

Enhancement of Apoptotic and Autophagic Induction by a Novel Synthetic C-1 Analogue of 7-deoxypancratistatin in Human Breast Adenocarcinoma and Neuroblastoma Cells with Tamoxifen
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Published on: May 30, 2012

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将尿素引入提拉巴胺衍生物中,以增强抗癌疗法

Yajun Xu1, Jianlin Lv1,2, Chaoying Kong1,2

  • 1Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.

National science review
|March 5, 2024
PubMed
概括

研究人员开发了新型含尿素的提拉帕扎胺 (TPZ) 衍生物,通过增加缺氧细胞毒性来增强抗癌疗效. 一种针对纤维素的纳米药物配方与血管破坏剂相结合,在临床前模型中显著抑制了瘤生长.

关键词:
结合拉斯塔丁A4的使用.低氧激活的前药物是低氧激活的前药物.提拉帕扎米因 (Tirapazamine) 是一种药物.尿素 urea 的使用方法血管破坏剂是一种血管破坏剂.

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