对生物药物的不良坚持和持久性在泛性性牛皮症中:基于声明的研究,使用来自两个大型美国数据库的真实世界数据
Steven R Feldman1, Rhonda L Bohn2, Ran Gao3
1Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, North Carolina.
JAAD international
|March 5, 2024
概括
在美国的一项研究中,针对泛性性牛皮 (GPP) 的生物药物的坚持和持续性通常很差. 改善患者坚持治疗对于更好的GPP治疗结果至关重要.
科学领域:
- 皮肤病学 皮肤病学
- 药物经济学 药物经济学
- 现实世界的证据.
背景情况:
- 泛性性牛皮 (GPP) 是一种罕见的,严重的皮肤病.
- 具有广泛无菌的特征,GPP显著影响患者的生活质量.
研究的目的:
- 评估在被诊断为GPP的患者中对生物疗法的坚持和持久性.
- 在现实环境中识别影响生物治疗坚持和持续性的因素.
主要方法:
- 使用美国MarketScan和Optum数据库进行的回顾性队列研究 (2015年10月 - 2020年3月).
- 包括18岁以上的新诊断的GPP患者 (ICD代码L40.1) 和特定的医疗保健索赔标准.
- 分析了生物分发,依从性治疗所覆盖日数 (PDC) 的比例,以及持久性治疗的持续时间.
主要成果:
- 生物药物在数据库中被14-22%的GPP患者使用.
- 良好的坚持 (≥80% PDC) 是不常见的 (24-36%),平均PDC为59-65%.
- 平均持续时间为261-287天;年轻的成年人 (18-64岁) 比老年人 (≥65岁) 持久度更高,持久度更长.
结论:
- 在GPP患者中,生物制剂的坚持和持续性通常不理想.
- 通过提高患者对生物疗法的坚持,可以改善治疗结果.
- 依据生物类,数据源和患者年龄的依赖性和持续性有所不同.
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