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瘤切除的骨切除术后SSRI使用是否是内出血的危险因素?

Bradley J Estes^1,2, Ahmad R Masri², Roukoz Chamoun²

¹The University of Kansas Medical Center, School of Medicine, Kansas City, KS, USA.

World neurosurgery: X

|March 5, 2024

概括

在脑外科手术前使用选择性血红素再吸收抑制剂 (SSRI) 不会增加出血风险. 这项研究发现,瘤切除的骨切除术患者的内出血率没有显著差异.

科学领域:

神经外科神经外科
药理学药理学是指药理学的学科.
临床结果临床结果

背景情况:

选择性血红素再吸收抑制剂 (SSRI) 与出血风险有关.
在脑瘤切除后,外科手术期间使用SSRI对内出血 (ICH) 的影响尚未得到充分证实.

研究的目的:

评估外科手术期间使用SSRI与选择性骨切除瘤切除后的ICH风险之间的关联.

主要方法:

对18岁以上的患者进行瘤切除选择性骨切除的电子病历的回顾性审查 (2010-2019).
术前使用SSRI的患者与未使用SSRI的患者之间的ICH发生率和风险的比较.
使用后勤回归分析来确定相对风险.

主要成果:

在1061名患者中,265人 (25%) 在外科期间使用SSRI.
ICH发生在3.0% (1周) 和4.2% (1月) 的SSRI使用者中.
在非SSRI使用者中,ICH发生在3.9% (1周) 和5.0% (1月) 的患者中.
与外科手术期间使用SSRI相关的ICH的相对风险是无意义的 (0.692;95% CI:0.260 - 1.839;p = 0.460).

结论:

外科手术期间使用的SSRI似乎不会增加瘤切除的头骨切除术后一个月内出血的风险.
在控制出血并发症和人口统计数据后,研究结果保持一致.

关键词:

内出血内出血风险因素风险因素风险因素选择性血清素再吸收抑制剂选择性血清素再吸收抑制剂

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