鼻腔和血清免疫球蛋白E水平在症状过敏鼻炎患者:一个病例对照研究
Mohan Raghav Guthikonda1, Danda Manimala2, Sirish Aryasomayajula2
1INHS Kalyani, Gandhigram, Visakhapatnam, Andhra Pradesh 530005 India.
概括
过敏性鼻炎患者的鼻腔和血清免疫球蛋白E (IgE) 水平显著上升. 鼻腔IgE与疾病的严重程度相关,这表明它在过敏性鼻炎的发病过程中发挥了作用.
科学领域:
- 免疫学 免疫学 免疫学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 过敏性鼻炎 (AR) 涉及由免疫球蛋白E (IgE) 驱动的鼻炎.
- 在鼻膜粘膜中观察到IgE升高,独立于血清IgE和亚托皮状态.
- 鼻腔粘膜可以在AR患者中本质上产生IgE.
研究的目的:
- 在有症状的AR患者中检查鼻腔和血清总IgE水平.
- 在AR和对照组中探索鼻腔和血清总IgE之间的相关性.
- 评估与严重过敏症状相关的风险因素.
主要方法:
- 一项涉及203名AR患者和203名健康对照者的病例控制研究.
- 测量鼻腔和血清总IgE水平.
- 使用t测试和后勤回归模型进行统计分析.
主要成果:
- 与对照组相比,具有症状的AR患者的平均鼻 (103.9 IU/ml) 和血清 (291.4 IU/ml) IgE水平显著更高 (分别为17.5 和 67.5 IU/ml).
- 后勤回归表明AR严重程度与鼻腔总IgE水平之间存在显著的关联.
- 在AR组中发现了鼻腔和血清IgE之间的正相关性,但在对照组中没有.
结论:
- 在有症状的AR患者中,鼻腔和血清IgE水平显著升高.
- 鼻腔IgE水平与AR严重程度相关,这表明它在疾病发病过程中发挥了作用.
- 需要进一步研究AR内型的鼻腔和血清IgE之间的相互作用.
相关概念视频
02:06Allergic Reactions
27.4K
Overview
27.4K
01:10Antibody Structure
60.1K
Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
60.1K
01:25Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
294
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
294