人类乳头瘤病毒感染与桃体癌的关联:系统性审查
Sneha Sethi1, Alana Shahin2, Intisar Nuha Abd Rahim2
1Australian Research Center for Population Oral Health, Adelaide Dental School, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, SA 5000 Australia.
人类乳头瘤病毒 (HPV) 疫苗接种减少了宫癌,但口腔癌正在增加. 这项审查发现50%的桃体癌与HPV有关,质疑预防性桃体切除术的有效性.
科学领域:
- 在瘤学瘤学.
- 病毒学 病毒学
- 公共卫生 公共卫生
背景情况:
- 接种HPV疫苗减少了宫癌,但口腔癌,包括桃体癌,正在增加.
- 建议进行预防性桃体切除术,以减少与HPV相关的口腔和桃体癌症.
- 支持HPV相关桃体癌的预防性桃体切除术的全球证据有限.
研究的目的:
- 为了估计与口腔喉HPV感染相关的桃体癌的综合流行率.
- 为了评估由于口腔瘤HPV感染导致的桃体癌的负担.
- 评估预防性桃体切除术的潜在作用.
主要方法:
- 发表文章的系统审查和元分析.
- 在PubMed,Embase,Scopus和Web of Science数据库中进行了搜索.
- 使用随机效应模型来估计聚合流行率.
主要成果:
- 在报告的桃体癌症病例中,有50%与口腔膜HPV感染有关.
- 在包括的研究中观察到显著的异质性.
- 数据不足阻止了子组分析.
结论:
- 桃体癌中50%的HPV患病率引发了人们对桃体切除术的预防益处的质疑.
- 需要进一步的研究来澄清HPV感染和桃体癌症之间的相关性.
- 需要更多的代表性研究来验证发现并为临床策略提供信息.
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