过敏性鼻炎的模式和严重程度与患者特征相关:一个农村医院的横截面研究
Ajinkya Sandbhor1, Shraddha Jain1,2, Prasad Deshmukh2
1Department of Otorhinolaryngology, Symbiosis Medical College for Women, Pune, Maharashtra 412115 India.
概括
过敏性鼻炎 (AR) 的严重程度和模式与患者的特征和过敏原暴露有关,而不仅仅是遗传. 环境因素和表观遗传学可能导致这种呼吸系统疾病的发病率上升.
科学领域:
- 免疫学 免疫学 免疫学
- 环境健康 环境健康
- 流行病学 流行病学
背景情况:
- 在全球范围内,过敏性鼻炎 (AR) 发病率正在增加.
- 遗传学和表观遗传学是AR的潜在贡献者.
- 抗胰腺炎的严重程度会影响治疗选择,这可能与患者特定的因素有关.
研究的目的:
- 将患者的特征与AR模式和严重程度关联起来,以了解病理生理学.
- 在印度农村的第三级护理环境中识别过敏原敏感性模式.
- 研究环境因素和表观遗传学在AR中的作用.
主要方法:
- 对90名经过临床诊断的过敏性鼻炎患者进行前性观察性研究.
- 皮肤刺伤测试 (SPT) 证实了诊断,并确定了过敏原敏感性.
- 收集有关人口统计,过敏原暴露,职业,家族病史,性别,疾病严重程度和模式的数据.
主要成果:
- 大多数AR患者年龄在15-40岁之间.
- 医学学生和农民显示,中度至重度持续性AR的高率.
- 虫敏感性在整体和医学学生中最常见;花粉敏感性在农民中更为普遍.
- 超过50%的患者缺乏亚托皮的家族史.
结论:
- 抗胰腺炎的严重程度和类型受过敏原暴露,职业和环境因素的影响.
- 患者的特征,超出ARIA指南,对于有效的AR管理至关重要.
- 环境因素和表观遗传变化是AR发病率上升的重要因素,挑战了"卫生假设".
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