对食道状细胞癌的外科免疫疗法
Dan D Wei1,2,3, Jin M Fang1,3, Huan Z Wang1
1Esophageal and Gastrointestinal Tumor Center, Hefei Cancer Hospital, Chinese Academy of Sciences, Hefei, China.
免疫检查点阻塞 (ICB) 疗法,使用抗编程细胞死亡-1 (PD-1) /PD-1连接体 (PD-L1) 抗体,已经改变了食道状细胞癌 (ESCC) 治疗. 本综述探讨了ICB在外科手术期间ESCC管理方面的进展.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 胃肠道癌症研究研究
背景情况:
- 食道状细胞癌 (ESCC) 是全球最常见的食道癌组织学亚型.
- 目前的治疗方法包括化疗,放射治疗和手术,对ESCC患者的长期预后有限.
- 免疫检查点阻塞 (ICB) 疗法已成为ESCC治疗的重大进展.
研究的目的:
- 对ESCC临床免疫疗法中常用的ICB抗体进行审查.
- 讨论在术后ESCC治疗中将免疫疗法与化疗和放射疗法结合使用的进展情况.
- 为整个治疗过程中提供ESCC综合性临床管理的见解.
主要方法:
- 在ESCC中对临床免疫治疗研究的文献综述.
- 对ESCC的术后治疗策略的进展进行分析.
- 简要介绍ICB抗体及其在ESCC管理中的应用.
主要成果:
- ICB治疗,特别是抗PD-1/PD-L1抗体,在ESCC中显示出显著的临床益处.
- ICB已经成为高级ESCC的标准一线治疗.
- 术前免疫疗法是一个新兴领域,正在进行研究和开发.
结论:
- ICB疗法代表了ESCC治疗的范式转变,改善了患者的治疗结果.
- 在外科手术期间将ICB与传统疗法结合在一起,对ESCC管理具有重大前景.
- 对手术前免疫疗法的进一步研究对于优化整个治疗范围内的ESCC患者护理至关重要.
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