人类长寿的等离子体蛋白质组签名
Xiaojuan Liu1, Gisli Thor Axelsson2,3, Anne B Newman4
1Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, California, USA.
Aging cell
|March 5, 2024
概括
研究人员确定了与长寿相关的关键蛋白质,在预测90岁以上的生存率方面表现优于传统因素. 这一发现为健康衰老提供了潜在的生物标志物和治疗点.
科学领域:
- 老年学和蛋白质组学
- 生物标志物发现发现
- 衰老研究研究 衰老研究
背景情况:
- 以前的蛋白质组学研究主要集中在时间学年龄上,而不是长寿.
- 确定健康衰老的蛋白质点可能会导致延长人类健康寿命的干预措施.
研究的目的:
- 评估长寿的蛋白质组特征,定义为生存到90岁的年龄.
- 为了确定蛋白质生物标志物和健康衰老和与年龄有关的疾病的潜在治疗点.
主要方法:
- 在两个大型前性队列 (CHS和AGES-雷克雅未克) 中利用了血蛋白质组学 (SOMAscan测定).
- 使用后勤回归和LASSO与交叉验证来识别和构建基于蛋白质的预测模型.
- 使用传统因素验证了模型,并评估了身体和认知功能的调解.
主要成果:
- 确定了105种与长寿相关的重复显著蛋白质,其中GDF-15和N端亲BNP是最重要的.
- 一个33蛋白模型在预测长寿方面显著优于传统的因素模型 (AUC在发现时从0.658提高到0.748).
- 169种蛋白质的关联部分是由身体和/或认知功能介导的.
结论:
- 这项研究发现了长寿的强有力的蛋白质原子特征.
- 开发的基于蛋白质的模型对预测健康衰老和优于传统模型的表现非常有希望.
- 研究结果表明,针对旨在延缓衰老和与年龄有关的疾病的干预措施,潜在的生物标志物和治疗目标.
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