劳动力对药物基因组学的准备以及退伍军人卫生管理局内维持工作的关键要素
Rebekah Ryanne Wu1,2, Richelle Benevent3, Nina R Sperber1,2,4
1Division of General Internal Medicine, Precision Medicine Program, Department of Medicine, Duke University, Durham, NC 27708, USA.
Pharmacogenomics
|March 5, 2024
概括
医疗保健提供者看到药物基因组学 (PGx) 的价值,以提高药物的疗效和安全性. 然而,他们对自己的知识和实施PGx的能力缺乏信心,这凸显了对全系统教育计划的需求.
科学领域:
- 药物基因组学 药物基因组学
- 临床药房 临床药房
- 医疗保健服务研究 医疗服务研究
背景情况:
- 药物基因组学 (PGx) 有潜力通过预测药物反应来个性化药物.
- 将PGx应用到常规临床实践中面临重大障碍.
- 退伍军人健康管理局 (VA) 试图了解这些障碍和促进国家计划发展的因素.
研究的目的:
- 在VA内确定药物基因组学实施的障碍和促进者.
- 确定VA国家临床药物基因组学计划的最佳结构.
主要方法:
- 在20个VA设施中对医疗保健提供者 (HCP) 进行的一项调查评估了PGx的知识和接受度.
- 与关键利益相关者进行的定性访谈探讨了设计和维持国家PGx计划的策略.
主要成果:
- 大多数受访的医疗保健工作者 (74.7%) 认为PGx会影响药物的疗效,71.0%的人认为它会影响不良事件.
- 然而,很大一部分医疗保健人员对自己的PGx知识 (43.0%) 和实施能力 (35.4-43.5%) 的信心很低.
- 接受采访的人强烈支持国家PGx教育,咨询和IT资源计划,并规定医疗保健人员领导当地努力.
结论:
- 医疗保健提供者承认药物基因组学的临床实用性,但目前尚未准备好广泛实施.
- 医疗保健系统必须建立全面的全系统计划,为成功的PGx集成提供教育和支持.
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