含糖饮料,遗传易感性和发生性心房:一项前性队列研究
Ying Sun1, Bowei Yu1, Yuefeng Yu1
1Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, China (Y.S., B.Y., Y.Y., B.W., Y.L., K.Z., N.W.).
Circulation. Arrhythmia and electrophysiology
|March 5, 2024
概括
含糖饮料 (SSB) 和人工甜味饮料 (ASB) 的高消费与心房动 (AF) 的风险增加有关. 纯果汁 (PJ) 消费显示了与AF的适度保护性关联. 遗传风险并没有显著改变这些饮料-AF关联.
科学领域:
- 心脏病学 心脏病学
- 营养科学 营养科学
- 流行病学 流行病学
背景情况:
- 含糖饮料的消费与心脏代谢疾病有关,但其与心房动 (AF) 的关联尚不清楚.
- 研究含糖饮料 (SSB),人工甜饮料 (ASB) 和纯果汁 (PJ) 对AF风险的影响至关重要.
研究的目的:
- 检查SSB,ASB和PJ消费与发展AF的风险之间的关联.
- 为了确定遗传敏感性是否会改变饮料消费和AF风险之间的关系.
主要方法:
- 利用可用遗传数据和饮食信息的大型队列 (201,856名参与者) 上的考克斯比例危险模型.
- 在9.9年的中位数随访期间评估发生的AF病例,并对多个变量进行调整.
主要成果:
- 每周消耗超过2升的SSB或ASB与显著增加的AF风险相关 (HR分别为1.10和1.20).
- 摄入≤1L/周的PJ与降低AF风险相关 (HR 0.92).
- 高遗传风险的个体每周摄入超过2升的ASB显示出最高的AF风险 (HR 3.51),而低遗传风险的个体每周摄入≤1升的PJ显示出最低的风险 (HR 0.77).
结论:
- 高摄入的SSB和ASB (>2L/周) 与增加的AF风险有关,而中度的PJ摄入 (≤1L/周) 可能具有保护作用.
- 饮料消费似乎可以预测AF风险,而不依赖于遗传倾向.
- 虽然观察到关联,但这项研究表明,SSB和ASB的消费可能预测AF风险,而不是直接改变它.
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