在精神分裂症患者中异常的甲状腺皮层连接和休息状态和任务状态之间的转移
Yoshifumi Takai1, Shunsuke Tamura1,2, Nobuhiko Hoaki3
1Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
The European journal of neuroscience
|March 5, 2024
概括
精神分裂症患者表现出异常的大脑连接. 他们的垂体-听觉网络在休息时过度连接,但在听觉任务期间连接不足,表明状态转移受损.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 精神分裂症与听觉处理缺陷和大脑网络失联有关.
- 以前的神经成像研究经常单独检查休息状态或与任务相关的连接性.
研究的目的:
- 在听觉平稳状态响应 (ASSR) 任务中调查血液氧气水平依赖 (BOLD) 信号.
- 分析休息状态和ASSR状态中的功能连接.
- 检查精神分裂症中休息状态和ASSR状态之间的状态转移.
主要方法:
- 在25名精神分裂症患者和25名对照中使用静止状态和稀疏采样听觉fMRI.
- 管理的听觉刺激 (点击列车在20,30,40,80 Hz).
- 检查了在甲状腺-听觉网络中的功能连接性.
主要成果:
- 精神分裂症组在80 Hz ASSR期间在听觉皮层和丘脑中显示出减少的BOLD信号.
- 在休息状态和ASSR状态之间的功能连接中发现了反向关系.
- 在精神分裂症中观察到更强的静止状态连接和减少ASSR任务连接,与异常状态转移有关.
结论:
- 精神分裂症涉及异常的甲状腺皮层连接.
- 在精神分裂症患者中,休息状态和任务状态之间转移的缺陷存在.
- 改变的功能连接动态突出了精神分裂症中关键的神经机制.
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