一种母乳寡糖在成年时通过调节肠道微生物代谢来预防肠炎
Kasey M Schalich1, Matthew A Buendia1, Harpreet Kaur1
1Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
mBio
|March 5, 2024
概括
人类牛奶的寡糖2'-富可酸乳糖 (2'-FL) 促进有益的肠道细菌,并产生泛酸盐,防止结肠炎. 这表明2'-FL可以通过恢复肠道微生物平衡来预防炎症性肠道疾病.
科学领域:
- 微生物学 微生物学
- 营养科学 营养科学
- 胃肠病学 胃肠病学
背景情况:
- 人类牛奶寡糖 (HMO) 已知会影响肠道微生物群,但它们的具体机制和治疗潜力尚不清楚.
- 最丰富的HMO-2-fucosyllactose (2-FL) 对婴儿健康至关重要,但它在成人肠道健康和疾病预防方面的作用需要进一步研究.
研究的目的:
- 研究2 -FL如何通过调节肠道微生物群落及其代谢输出来预防成年小鼠的结肠炎.
- 为了确定2 -FL消费产生的特定微生物代谢物,并评估它们对肠道屏障的保护作用.
主要方法:
- 成年小鼠被食2-FL,并分析了它们的肠道微生物群组成和功能.
- 探索性代谢学被用来识别由消耗2 -FL的Bifidobacterium infantis分泌的代谢物.
- 已识别的代谢物对氧化应激和结肠炎的保护作用在小鼠中进行了评估.
主要成果:
- 2 -FL的消费增加了像Bifidobacterium和Lactobacillus这样的有益细菌,从而提供了对大肠炎的保护.
- 潘托醇被确定为由B.产生的一种新型2-FL丰富代谢物. 婴儿的孩子们.
- 潘托酸显著地保护了肠道屏障免受氧化应激和缓解性结肠炎的影响.
结论:
- 2 -FL形的肠道微生物群及其代谢产物,特别是托酸,有助于肠道完整性,并预防成人炎症.
- 2 -FL通过纠正性结肠炎中观察到的微生物代谢失调,显示出预防胃肠道疾病的潜力.
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